NRG Therapeutics is a neuroscience drug discovery company building a pipeline of disease modifying drug candidates, focused on therapeutic approaches that will restore mitochondrial function and slow or halt the progression of neurodegenerative diseases such as Parkinson’s, Alzheimer’s and MND, or amyotrophic lateral sclerosis (ALS) as it is also known.
The company’s pre-clinical pipeline of small molecule assets is based on inhibiting the mitochondrial permeability transition pore. Inhibition of the mPTP has been shown to protect neurons, reduce neuroinflammation and extend survival in pre-clinical disease models.
Based in Cambridge, UK, NRG Therapeutics is a private company with equity investment from the Parkinson’s Virtual Biotech, the drug development arm of Parkinson’s UK, and grant funding from Innovate UK and charitable organisations including The Michael J. Fox Foundation.